Custom Peptides
Cayman Chemical Sulfonadyn-47 10mg
A dynamin inhibitor; inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM); inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM); has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures at 30 and 60 mg/kg
Cayman Chemical FlavokawaIn C 10mg
A chalcone with enzyme inhibitory and anticancer activities; inhibits collagenase and elastase in cell-free assays (IC50s = 62.05 and 17.6 µM, respectively); cytotoxic to HCT116, HT-29, MCF-7, A549, and Ca Ski cancer cells (IC50s = 12.75, 39, 47.63, 40.28, and 39.88 µM, respectively); induces apoptosis and cell cycle arrest at the G1 phase in HCT116 cells at 20, 40, and 60 µM; reduces tumor volume and induces intratumoral necrosis and apoptosis in an HCT116 mouse xenograft model at 1 and 3 mg/kg
Cayman Chemical DIhydromyrIstIcIn 10mg
A derivative of myristicin; induces GST activity in the liver and small intestinal mucosa but not the forestomach, lungs, large intestinal mucosa, or bladder in mice at 20 mg/animal
Cayman Chemical MoexIprIlat 10mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day
Cayman Chemical 28Deoxybetuln mthylenamIn 10mg
A derivative of betulin; has been used in the synthesis of triterpene derivatives with antiviral activity
Cayman Chemical PSB-1115potasIum salt 10mg
An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical LeteprInImpotasIum salt 10mg
A nootropic and neuroprotective agent and a derivative of hypoxanthine; enhances NGF-induced neurite growth in PC12 cells at 10 and 100 µM and increases the production of synaptophysin at 5-100 ng/ml; enhances working memory in a win-shift T-maze in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate age-induced memory deficits at 30 mg/kg; reduces impairments in locomotor function in rats and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord at 60 mg/kg per day for 21 days in a rat model of spinal crush injury; reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1, CA3, and dentate gyrus regions and decreases the number of caspase-3 and TUNEL-positive cells in the hippocampus and prefrontal and parietal cortices in neonatal rats at 60 mg/kg
Cayman Chemical EsmololhydrochlorIde 10mg
A β1-AR antagonist; binds to β1-ARs (Kd = 100 nM in isolated cardiac myocytes); 34-fold selective for β1- over β2-ARs; inhibits ICa.L and the INa in rat cardiac myocytes (IC50s = 50 and 169 μM, respectively)
Cayman Chemical BIA 10-2474 10mg
An inhibitor of FAAH (IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme); inhibits FAAH2, ABHD6, CES2, and PNPLA6 (IC50s = 0.4, 0.081, 2, and 11 μM, respectively); alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity
Cayman Chemical C17 CeramIded18 117 0 10mg
A synthetic ceramide; contains a non-natural C17:0 fatty acid acylated to sphingosine; has been used as a marker of arylsulfatase A and sphingolipid activator B activity
Cayman Chemical PravastatIn lacton 10mg
A metabolite of pravastatin; formed when pravastatin undergoes acid catalyzed non-enzymatic lactonization in the stomach
Cayman Chemical ApatInIb-d8 10mg
An internal standard for the quantification of apatinib by GC- or LC-MS
Cayman Chemical 1 2bIs heptnoylthIo GlycR 10mg
Diheptanoyl Thio-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH.{5681} Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.{1358,1359}
Cayman Chemical R-2 MethndamIde 10mg
A CB analog with a methyl group in the (R) configuration at C-2 of the ethanolamine group; is not a FAAH inhibitor and is nearly as susceptible to amide hydrolysis as AEA itself
Cayman Chemical DIbutyl3Hydroybutyl phsph 10mg
A compound produced from the metabolism of the organophosphorus solvent, TBP